Lupus & antiphospholipid syndrome
Right ventricular-pulmonary arterial coupling ratio derived from 3-dimensional echocardiography predicts outcomes in systemic lupus erythematosus-associated pulmonary arterial hypertension patients
Authors' conclusion
The 3DE-derived SV/ESV ratio as a noninvasive alternative surrogate of RV-PA coupling was an eximious indicator for identifying endpoint events in SLE-PAH patients
Study context
- Population
- Consecutive patients with SLE-PAH, June 2019 to February 2023
- Participants
- 46 SLE-PAH patients
- Exposure
- SLE-PAH patients vs healthy controls; RVSV/right ventricular end-systolic volume (RVESV) ratio by 3DE
- Controlsn = 30reference
- SLE-PAH with endpoint eventn = 16
- Outcome
- Composite of:
- All-cause mortality
- Adverse clinical events
Methodological detailsconsecutive enrolment, healthy controls matched for age, sex and body surface area (BSA)
- Consecutive enrolment
- Healthy controls matched for age, sex and BSA
Main finding
As reported in the abstract
Endpoint-related events · median 24 months (IQR 18-31)
SLE-PAH with endpoint event
34.7%
16
Observational data: associations, not effects.
Further findings
| Outcome | Controls | SLE-PAH without endpoint event | SLE-PAH with endpoint event | P value |
|---|---|---|---|---|
| RVSV/RVESV ratioSLE-PAH with endpoint event vs Controls · three-group comparison | 1.86 (range 1.65–2.3) | 1.30 (range 1.09–1.46) | 0.64 (range 0.59–0.67) | P < 0.001 |
Correlation of RVSV/RVESV ratio with WHO FC
- Negative correlation (r)
- −0.621
- P
- P < 0.001
- Positively correlated with anti-dsDNA level
Prognostic cutoff of RVSV/RVESV (ROC)
- Optimal cutoff; RVSV/RVESV < 0.712 higher risk of poor prognosis
- Kaplan-Meier: ratio >0.712 associated with more favourable long-term outcomes
Original publication
Right ventricular-pulmonary arterial coupling ratio derived from 3-dimensional echocardiography predicts outcomes in systemic lupus erythematosus-associated pulmonary arterial hypertension patients. Lupus. Published 5 January 2024. doi:10.
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