Lupus & antiphospholipid syndrome
Incidence of serious infections, herpes zoster and hepatitis B virus reactivation among patients with SLE: a cohort study using a health claims database in Japan
Authors' conclusion
These results provide data on the occurrence of selected infections in SLE
Study context
- Population
- Patients with SLE in a Japanese insurance claims database, 1 April 2017 to 31 March 2021 (female: 83.1%, median age: 53.0 years)
- Participants
- 10,865 patients
- Outcome
- Incidence of SI requiring hospitalisation, HZ and HBV reactivation (per 100 patient-years)
Methodological detailsnon-interventional, insurance claims database, exploratory analysis adjusted for age and sex
- Non-interventional
- Insurance claims database
- Exploratory analysis adjusted for age and sex
Main finding
As reported in the abstract
Incidence rates per 100 patient-years, including those with previous complication
Serious infections (SI)
4.80
95% CI 4.53 to 5.08
Herpes zoster (HZ)
0.52
95% CI 0.44 to 0.61
Hepatitis B virus (HBV) reactivation
0.37
95% CI 0.30 to 0.45
Observational data: associations, not effects.
Further findings
Incidence rates per 100 patient-years, no previous history of each complication
- SI
- 3.67 (95% CI 3.44 to 3.92)
- HZ
- 0.48 (95% CI 0.40 to 0.58)
- HBV reactivation
- 0.25 (95% CI 0.20 to 0.32)
Incidence rates in subgroup with history of each complication
- SI
- 37.93
- HZ
- 4.19
- HBV reactivation
- 72.01
Incidence rates in subgroup with history of SI
- HZ
- 1.51
- HBV reactivation
- 1.75
Incidence rates in subgroup with GC pulse therapy during follow-up
- SI
- 64.23
- HZ
- 3.10
- HBV reactivation
- 4.85
Original publication
Incidence of serious infections, herpes zoster and hepatitis B virus reactivation among patients with SLE: a cohort study using a health claims database in Japan. Lupus Sci Med. Published 17 May 2026. doi:10.
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