Lupus & antiphospholipid syndrome
Aberrant sphingosine-1-phosphate receptor 1 expression on activated naive B cells associated with disease activity and lupus nephritis in systemic lupus erythematosus
Authors' conclusion
Surface S1PR1 expression was downregulated in aNAV and DN2 B cells. Clinically, decreased surface S1PR1 expression on aNAV B cells was significantly correlated with active status, increased disease activity, LN involvement, and elevated ESR.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE); Peripheral blood mononuclear cells (PBMCs) assessed for S1PR1 expression in B cell subsets and plasma cells
- Participants
- 49 patients
- Outcome
- S1PR1 expression in B cell subsets and plasma cells
Main finding
As reported in the abstract
- Intracellular S1PR1 expression significantly increased across all B cell subsets (rNAV, activated naive (aNAV), SWM, USM, DN1, DN2) and antibody-secreting cells (ASCs)
- Surface S1PR1 downregulated in aNAV and DN2 B cells, upregulated in ASCs
- Surface S1PR1 downregulation on aNAV B cells significantly associated with active disease status, SLEDAI-2K scores and Lupus Nephritis (LN) involvement
Further findings
Inflammatory markers vs surface S1PR1 expression
- IL-6, IL-8 and C3c levels showed no correlation with surface S1PR1 expression
- Erythrocyte sedimentation rate (ESR) showed a significant negative correlation
Surface CXCR3 expression
- Lupus aNAV and DN2 B cells had reduced surface CXCR3 without correlation to S1PR1 expression
- Other B cell subsets in SLE showed significant correlation between CXCR3 and S1PR1 expression
Original publication
Aberrant sphingosine-1-phosphate receptor 1 expression on activated naive B cells associated with disease activity and lupus nephritis in systemic lupus erythematosus. Arthritis Res Ther. Published 14 May 2026. doi:10.
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