Lupus & antiphospholipid syndrome
Expression and significance of NF-κB and HSP90 in renal puncture tissues and peripheral blood mononuclear cells of patients with lupus nephritis
Authors' conclusion
NF-κ B and HSP90 may play a synergistic role in the pathogenesis of LN. Their elevated expression has a high diagnostic accuracy for LN or SLE without renal damage.
Study context
- Population
- Patients with lupus nephritis (LN), patients with systemic lupus erythematosus (SLE) and controls, single hospital
- Participants
- 52 / 32 / 12 / 16 / 16
- Comparison
- LN vs controls; LN vs SLE vs healthy controls
- LNn = 52
- Controln = 32reference
- LN (PBMC)n = 12
- SLEn = 16
- Healthy controlsn = 16reference
- Outcome
- Expression of NF-κB and HSP90 in kidney tissue and PBMCs
Methodological detailscase-control
- Case-control
Main finding
As reported in the abstract
NF-κB and HSP90 expression
- High NF-κB and HSP90 protein expression associated with severe LN activity (SLEDAI >15)
- p<0.05
- NF-κB and HSP90 mRNA in peripheral blood mononuclear cells (PBMCs) up-regulated in SLE vs controls
- p<0.05
- NF-κB and HSP90 mRNA in PBMCs up-regulated in LN vs SLE
- p<0.05
- NF-κB and HSP90 mRNA in PBMCs of LN positively correlated
- p<0.05
Further findings
| Outcome | NF-κB mRNA | HSP90 mRNA |
|---|---|---|
| Diagnosis of SLE kidney damage by PBMC mRNA expression (ROC) | ||
| AUC | 0.929 (95% CI 0.833-1.000, p<0.001) | 0.742 (95% CI 0.556-0.927, p<0.05) |
Original publication
Expression and significance of NF-κB and HSP90 in renal puncture tissues and peripheral blood mononuclear cells of patients with lupus nephritis. Clin Exp Rheumatol. Published 12 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →