Lupus & antiphospholipid syndrome
Fibromyalgia, mood disorders and chronic damage are the main determinants of worse quality of life in systemic lupus erythematosus patients: Results from a cross-sectional analysis
Authors' conclusion
In particular, the presence of mood disorders, fibromyalgia and chronic damage resulted the main determinants of poorer QoL.
Study context
- Population
- Consecutive Systemic Lupus Erythematosus (SLE) patients diagnosed per the 2019 ACR/EULAR criteria (92.4% female, median age 46 years)
- Exposure
- SLE patients with vs without chronic damage, fibromyalgia, anxiety and depression
- SLICC Damage Index (SDI) ≥ 1n = 104
- Fibromyalgian = 69
- Anxietyn = 112
- Depressionn = 94
- Outcome
- QoL (LupusQoL) and its main determinants
Methodological detailsconsecutive patients, linear regression analysis
- Consecutive patients
- Linear regression analysis
Main finding
As reported in the abstract
Determinants of worse QoL (LupusQoL)
- Significantly lower values in all LupusQoL domains in patients with fibromyalgia, anxiety and depression vs those without
- p < .0001
Observational data: associations, not effects.
Further findings
Disease activity and damage at enrollment
- SLEDAI-2k, mean (DS 2.4)
- 1.7
- Chronic damage, patients (43.9%)
- 104
- SDI, mean (DS 1.3)
- 0.8
- Fibromyalgia, patients (29.1%)
- 69
- Anxiety, patients (47.3%)
- 112
- Depression, patients (39.7%)
- 94
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Fibromyalgia, mood disorders and chronic damage are the main determinants of worse quality of life in systemic lupus erythematosus patients: Results from a cross-sectional analysis. Lupus. Published 11 November 2024. doi:10.
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