Lupus & antiphospholipid syndrome
Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis
Authors' conclusion
Renal histologic findings may reflect the different pathogeneses involved in each lesion, and estimating the urinary calgranulin B, MCP-1, and IGFBP-5 levels may be useful in predicting the presence and severity of histologic findings in LN.
Study context
- Population
- Patients with biopsy-proven active lupus nephritis (LN)
- Outcome
- Urinary proteins associated with histologic findings in LN
Methodological detailsaptamer-based proteomic assay, validation cohort, immunohistochemical staining
- Aptamer-based proteomic assay
- Validation cohort
- Immunohistochemical staining
Main finding
As reported in the abstract
- Cluster analysis extracted five histologic subgroups by correlation with each histologic finding
- Protein groups correlated with each histologic subgroup revealed a distinct pathogenesis in LN (pathway analyses)
- On ELISA validation, urinary calgranulin B (S100A9), MCP-1 and IGFBP-5 levels specifically predicted presence and severity of active glomerular lesions, interstitial inflammation and interstitial fibrosis, respectively
- Immunohistochemistry localised these proteins in each lesion
- 1,305 proteins screened
Original publication
Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis. Arthritis Rheumatol. Published 11 November 2024. doi:10.
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