Lupus & antiphospholipid syndrome
Clinical significance of exostosin 1 in confirmed and suspected lupus membranous nephropathy
Authors' conclusion
The EXT1-positive group exhibited a higher active index and a more favourable renal outcome than the EXT1-negative group.
Study context
- Population
- Renal tissues of phospholipase A2 receptor (PLA2R)-negative and ANA-positive membranous nephropathy
- Participants
- 67 renal tissues
- Exposure
- EXT1-positive vs EXT1-negative; confirmed lupus membranous nephropathy (LMN) vs suspected LMN
- Outcome
- EXT1 positivity in confirmed and suspected LMN
Methodological detailsimmunohistochemistry
- Immunohistochemistry
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
EXT1 positivity in pure vs mixed class V LN (confirmed LMN subgroup)
P = 0.007
- Clinicopathological data, EXT1-positive vs EXT1-negative (confirmed and suspected LMN)
- P < 0.05
- Complete remission post-treatment (follow-up) · EXT1-positive vs EXT1-negative
- P < 0.05
- Accumulated nephrotic remission, whole cohort (Kaplan-Meier) · EXT1-positive vs EXT1-negative
- P = 0.028
EXT1 positivity in pure vs mixed class V lupus nephritis (LN) (confirmed LMN subgroup)
- Pure class V LN showed lower frequency of EXT1 positivity than mixed class V LN
Clinicopathological data, EXT1-positive vs EXT1-negative (confirmed and suspected LMN)
- Significant differences in some clinicopathological data
Complete remission post-treatment (follow-up)
- Greater proportion achieved complete remission in EXT1-positive group
Accumulated nephrotic remission, whole cohort (Kaplan-Meier)
- Higher rate of accumulated nephrotic remission in EXT1-positive group
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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