Lupus & antiphospholipid syndrome
Transcriptomic features of systemic lupus erythematosus patients in flare and changes during acute in-hospital treatment
Authors' conclusion
In-hospital treatment significantly relieved SLE symptoms with expression changes of a small subset of genes.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients in flare receiving in-hospital treatment, and healthy controls
- Participants
- 65 / 65 / 15
- Comparison
- SLE flare before vs after in-hospital treatment, and vs healthy controls
- SLE1n = 65
- SLE2n = 65
- Healthy controls (HC)n = 15reference
- Outcome
- Transcriptomic changes (differentially expressed genes (DEGs)) in PBMCs
Methodological detailsRNA sequencing of peripheral blood mononuclear cells (PBMCs), before and after in-hospital treatment
- RNA sequencing of PBMCs
- Before and after in-hospital treatment
Main finding
As reported in the abstract
- Few upregulated genes in SLE1 vs HC were affected by treatment (SLE2 vs SLE1), mostly functional in IFN signalling, plasmablasts and neutrophils
- IFN and plasmablast signatures were repressed by treatment
- Neutrophil signature remained unchanged or enhanced by treatment
- IFN and neutrophil scores together stratified the SLE samples
- IFN scores correlated well with leukopenia; neutrophil scores reflected relative cell compositions but not cell counts
Original publication
Transcriptomic features of systemic lupus erythematosus patients in flare and changes during acute in-hospital treatment. Rheumatology (Oxford). Published 23 December 2023. doi:10.
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