Lupus & antiphospholipid syndrome
Renal tubular and glomerular estrogen receptor ß levels are lower in lupus nephritis than in familial Mediterranean fever-associated renal amyloidosis
Authors' conclusion
This study showed that tubular estrogen receptor ß expression score was elevated in familial Mediterranean fever amyloidosis and correlated with serum creatinine levels and renal crescents.
Study context
- Population
- Patients with LN, FMF amyloidosis or ANCA-associated glomerulonephritis and individuals with normal renal histology
- Participants
- 30 / 12 / 10 / 14
- Exposure
- Renal estrogen receptor expression in LN vs FMF-associated renal amyloidosis vs ANCA-associated nephritis vs normal renal histology
- Lupus nephritisn = 30
- FMF amyloidosisn = 12reference
- ANCAn = 10
- Normal renal histologyn = 14
- Outcome
- Tubular estrogen receptor ß expression score
Main finding
As reported in the abstract
FMF amyloidosis
5
range 1–8
Lupus nephritis
0
range 0–1
ANCA
4
range 1–6.5
- FMF amyloidosis vs ANCA · B = −1.431
- OR 0.239 (95% CI 0.093–0.614); P = 0.003
Observational data: associations, not effects.
Further findings
Correlation of serum creatinine with tubular estrogen receptor ß expression score
- OR
- 0.565
- 95% CI
- 0.622-1.402
- P
- P < 0.0001
ANCA-associated glomerulonephritis: fibro cellular crescents and glomerular estrogen receptor ß expression score
- OR
- 0.247
- 95% CI
- 0.11-0.999
- P
- P = 0.045
ANCA-associated glomerulonephritis: fibro cellular crescents and tubular estrogen receptor ß expression score
- OR
- 0.282
- 95% CI
- −0.180-2.812
- P
- P = 0.026
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →