Lupus & antiphospholipid syndrome
Post-COVID-19 depression and anxiety in patients with systemic lupus erythematosus
Authors' conclusion
Patients with SLE, who are already vulnerable to physiological stressors, are especially predisposed to more risk of anxiety and depression when they are contracted with COVID-19 disease. Furthermore, anxiety and depression are associated with SLE activity and damage scores, and COVID-19 infection is a significant predictor for their severity.
Study context
- Population
- Adult Egyptian patients with systemic lupus erythematosus (SLE) in the post-COVID-19 period
- Participants
- 120 patients
- Comparison
- SLE patients recovered from polymerase chain reaction (PCR)-proven SARS-CoV-2 infection vs SLE patients without SARS-CoV-2 infection
- Casesn = 60
- Outcome
- Depression and anxiety scores
Methodological detailsage- and sex-matched
- Age- and sex-matched
Main finding
As reported in the abstract
Mean depression and anxiety scores
- Mean depression and anxiety scores significantly higher in cases than in controls
Observational data: associations, not effects.
Further findings
Correlates of depression and anxiety scores
- Significant positive correlation with age, disease duration, SDI and SLE disease activity index (SLEDAI); significant negative correlation with education years
Predictors of severe depression and moderate-to-severe anxiety (hierarchical multivariate regression)
- COVID-19 infection was a predictor
Original publication
Post-COVID-19 depression and anxiety in patients with systemic lupus erythematosus. Lupus. Published 7 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →