Lupus & antiphospholipid syndrome
Pregnancy outcomes among Egyptian women with systemic lupus erythematosus: A prospective cohort study
Authors' conclusion
To conclude, unplanned pregnancy, disease flares, and APS have been identified as predictors for adverse maternal and/or fetal outcomes.
Study context
- Population
- Pregnant women with systemic lupus erythematosus (SLE) followed at a conjoint high-risk pregnancy/rheumatology clinic, Egypt, 2007–2021 (mean age 27.16 ± 4.80 years; mean disease duration 7.35 ± 5.46 years)singleton pregnancies of 123 women
- Participants
- 201 singleton pregnancies
- Outcome
- Pregnancy outcomes and predictors of adverse maternal and fetal outcomes
Methodological detailssingle conjoint high-risk pregnancy/rheumatology clinic, multivariate analyses
- Single conjoint high-risk pregnancy/rheumatology clinic
- Multivariate analyses
Main finding
As reported in the abstract
Pregnancy outcomes (of 201 pregnancies)
- Flares
- 83 (41.3%)
- Pre-eclampsia
- 15 (7.5%)
- Full-term pregnancy
- 93 (46.3%)
- Fetal loss (miscarriage and intra-uterine fetal death)
- 41 (20.4%)
- Prematurity
- 67 (33.3%)
- Neonatal deaths from complications of prematurity
- 7
- Neonatal death from cardiac congenital anomalies
- 1
Observational data: associations, not effects.
Further findings
Predictors of adverse outcomes (multivariate analyses)
| OR | P value | |
|---|---|---|
| Unplanned pregnancyDisease flare | 7.92 | P < 0.001 |
| LN flare during pregnancyPre-eclampsia | 3.98 | P = 0.02 |
| Disease flares during pregnancyPrematurity | 2.49 | P = 0.049 |
| Secondary APSFetal loss | 2.97 | P = 0.049 |
Baseline characteristics
- Secondary antiphospholipid syndrome (APS)
- 77 (38.3%)
- Planned pregnancy
- 104 (51.7%)
Original publication
Pregnancy outcomes among Egyptian women with systemic lupus erythematosus: A prospective cohort study. Lupus. Published 8 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →