Lupus & antiphospholipid syndrome
Long-term impact of pregnancy on renal function among Egyptian women with lupus nephritis: A case control study
Authors' conclusion
In conclusion, pregnancy, per se, does not affect the long-term renal outcome in LN patients; however, it is rather dependent on the existence of baseline renal damage and the development of renal flares.
Study context
- Population
- Egyptian women with LN
- Participants
- 43 vs 39
- Comparison
- First pregnancy after LN onset vs never pregnant after LN onset
- Group In = 43
- Group IIn = 39reference
- Outcome
- Long-term renal outcomes
- Follow-up
- Last visit (Tlast)
Methodological detailsretrospective
- Retrospective
Main finding
As reported in the abstract
Renal outcomes at Tlast:
- Serum creatinine
- eGFR
- Renal SDI
- Renal flares
- New-onset CKD
- Progressed CKD
- End-stage renal disease
- No significant difference between groups in serum creatinine, estimated glomerular filtration rate (eGFR), renal SLICC/ACR Damage Index (SDI), rate of renal flares, new-onset chronic kidney disease (CKD), progressed CKD and end-stage renal disease
Observational data: associations, not effects.
Further findings
Predictors of new-onset/progressed CKD (multivariate regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Systemic hypertension | 4 (1.3–13) | P = 0.019 | |
| Renal flares | 13.8 (1.5–128.8) | 0.022 | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Group I | Group II | P value |
|---|---|---|---|
| Predictors of new-onset/progressed CKD (multivariate regression)Pregnancy · not a predictor | P = 0.363 | ||
| Change T0 to Tlast within groups: increase in serum creatinine, renal SDI and CKD prevalence; decrease in eGFRPaired comparisons within each group; all significant | |||
| P serum creatinine | p = 0.004 | p = 0.006 | |
| P renal SDI | <0.001 | <0.001 | |
| P CKD prevalence | 0.001 | 0.004 | |
| P eGFR | <0.001 | 0.002 |
Original publication
Long-term impact of pregnancy on renal function among Egyptian women with lupus nephritis: A case control study. Lupus. Published 10 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →