Lupus & antiphospholipid syndrome
Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE
Authors' conclusion
Our study did not validate the differentially abundant proteins as markers for SLE-SGA but suggested a link between the antiangiogenic and proangiogenic proteins, endostatin and angiogenin, respectively, and pre-eclampsia in SLE.
Study context
- Population
- Pregnant women with SLE and healthy controls in the prospective SLE-Placenta study; plasma sampled repeatedly during pregnancy, at delivery and from placental intervillous bloodSLE n=83
- Participants
- 8 / 8 / 6
- Exposure
- SLE pregnancies complicated by small for gestational age (SGA) vs uncomplicated SLE pregnancies; SLE vs healthy controls
- SLE-SGAn = 8
- Uncomplicated SLEn = 8reference
- Healthy controlsn = 6
- Outcome
- Proteins associated with SGA in SLE
Methodological detailsproteomic discovery (mass spectrometry) with ELISA validation in full cohort, nested in the prospective SLE-Placenta study
- Proteomic discovery (mass spectrometry) with ELISA validation in full cohort
- Nested in the prospective SLE-Placenta study
Main finding
As reported in the abstract
Proteins with increased abundance in SLE-SGA vs uncomplicated SLE (discovery proteomics)
- ELISA in the full cohort did not confirm increased levels of these proteins in SLE-SGA
- SLE-SGA vs Uncomplicated SLE: P adj =0.0003
- SLE-SGA vs Uncomplicated SLE: P adj =0.03
- SLE-SGA vs Uncomplicated SLE: P adj =0.03
- SLE-SGA vs Uncomplicated SLE: P adj =0.004
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Endostatin levels, SLE vs controls · all trimestersConsistently higher in SLE | P ≤ 0.0001 |
Endostatin and angiogenin in women with SLE who later developed pre-eclampsia (ELISA)
- Suggested elevated levels of endostatin and angiogenin
Enrichment in placental blood
- Endostatin, but not angiogenin, enriched in placental blood
Original publication
Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE. Lupus Sci Med. Published 7 December 2025. doi:10.
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