Lupus & antiphospholipid syndrome
Placental lesions in systemic lupus erythematosus pregnancies associated with small for gestational age infants
Authors' conclusion
The higher prevalence of increased PVFD in placentas of SLE-associated SGA may indicate a specific mechanism of placental injury leading to SGA in this context.
Study context
- Population
- SLE deliveries with placental analysis at UCSD, November 2018 to October 2023placental analysis in 28/70 SLE deliveries
- Participants
- 12 / 16 / 36
- Exposure
- SLE pregnancies with small for gestational age (SGA) vs SLE pregnancies without SGA, and vs matched non-SLE pregnancies with SGA
- SLE SGAn = 12
- SLE non-SGAn = 16reference
- Non-SLE SGAn = 36reference
- Outcome
- Placental pathology associated with SGA infants in SLE
Methodological detailsmatched non-SLE SGA comparison, single-centre
- Matched non-SLE SGA comparison
- Single-centre
Main finding
As reported in the abstract
Placental lesions distinguishing SLE SGA vs SLE non-SGA
- SLE placentas with increased perivillous fibrin deposition (PVFD) resulting in SGA infants
- All seven
Observational data: associations, not effects.
Further findings
| Outcome | SLE SGA | Non-SLE SGA | P value |
|---|---|---|---|
| Increased PVFD, SLE SGA vs matched non-SLE SGA (only distinguishing lesion) | 58% | 22% | P = 0.03 |
Adverse outcomes in SLE deliveries with placental analysis
- Rate of adverse outcomes
- 75%
Original publication
Placental lesions in systemic lupus erythematosus pregnancies associated with small for gestational age infants. Rheumatology (Oxford). Published 28 August 2024. doi:10.
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