Lupus & antiphospholipid syndrome
The correlation between pregnancy, disease activity and adverse pregnancy outcomes in patients with systemic lupus erythematosus
Authors' conclusion
Postpartum six-month period appears to have the highest risk for disease flares during SLE pregnancies. Disease activity during pregnancy increases the risk of APO.
Study context
- Population
- Pregnant patients with systemic lupus erythematosus (SLE) under surveillance of Rheumatology and Obstetrics departments
- Participants
- 136 patients168 pregnancies
- Exposure
- Adverse pregnancy outcomes (APO)+ vs APO-
- Outcome
- Effects of pregnancy on disease activity (SLEDAI-2K pre/postpartum, SLEPDAI per trimester) and correlation between flares and APO
Main finding
As reported in the abstract
- Pregnancies with flares (pregnancy and 6 months postpartum)
- 60 (35.7%)
- Mean SLEDAI in 6 months postpartum significantly higher than during pregnancy
- p < .05
- APO observed
- 33.9%
Observational data: associations, not effects.
Further findings
Mean
| Outcome | APO+ | APO- | P value |
|---|---|---|---|
| Mean SLEPDAI score, APO+ vs APO- | 4.9 (SD 6.1) | 2.8 (SD 4.9) | P = 0.002 |
| SLICC damage score, APO+ vs APO- | 1.8 (SD 2.1) | 0.8 (SD 1.3) | P = 0.001 |
| Severe postpartum flares by LLDAS during pregnancyLLDAS vs Not in LLDAS | P < 0.05 |
- Severe postpartum flares by lupus low disease activity state (LLDAS) during pregnancy: LLDAS 11%
- Severe postpartum flares by LLDAS during pregnancy: Not in LLDAS 29%
Pregnancies in LLDAS during pregnancy
- In LLDAS during pregnancy
- 132 (78.6%)
Original publication
The correlation between pregnancy, disease activity and adverse pregnancy outcomes in patients with systemic lupus erythematosus. Lupus. Published 19 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →