Lupus & antiphospholipid syndrome
Pregnancy outcomes in 1869 pregnancies in a large cohort from the Spanish Society of Rheumatology Lupus Register (RELESSER)
Authors' conclusion
The likelihood of term pregnancy is higher before the diagnosis of SLE. In our cohort, positivity for anticardiolipin IgG and anti-beta-2- glycoprotein IgG/IgM, but not lupus anticoagulant, was associated with a higher risk of poorer pregnancy outcomes.
Study context
- Population
- Women with systemic lupus erythematosus (SLE) from the RELESSER register (Spanish Society of Rheumatology), after 12 years of follow-up
- Participants
- 809 women1,869 pregnancies
- Exposure
- Pregnancies before vs after SLE diagnosis; women with vs without pregnancy complications
- With complicationsn = 114
- Outcome
- Number of term pregnancies, before vs after SLE diagnosis
Methodological detailsmulticentre, retrospective observational, bivariate and multivariate analyses
- Multicentre
- Retrospective observational
- Bivariate and multivariate analyses
Main finding
As reported in the abstract
Term pregnancies
| Group | Value | Pregnancies per woman |
|---|---|---|
| Before diagnosis | 76.8% | 2.37 |
| After diagnosis | 69.8% | 1.87 |
Value
Before diagnosis76.8%
After diagnosis69.8%
Pregnancies per woman
Before diagnosis2.37
After diagnosis1.87
- Before diagnosis vs After diagnosis: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | Before diagnosis | After diagnosis | With complications | Without complications | P value |
|---|---|---|---|---|---|
| Age at SLE diagnosis | 43.4 years | 34.1 years | — not stated in the abstract | — not stated in the abstract | |
| APSWith complications vs Without complications | — not stated in the abstract | — not stated in the abstract | 40.5% | 9.9% | P < 0.001 |
| IgG aCL positivityWith complications vs Without complications | — not stated in the abstract | — not stated in the abstract | 33.9% | 21.3% | P = 0.005 |
| IgG anti-beta 2 glycoprotein positivityWith complications vs Without complications | — not stated in the abstract | — not stated in the abstract | 26.1% | 14% | P = 0.007 |
| IgM anti-beta 2 glycoprotein positivityWith complications vs Without complications | — not stated in the abstract | — not stated in the abstract | 26.1% | 16% | P = 0.032 |
— not stated in the abstract
Age at SLE diagnosis
- Before-diagnosis group had more comorbidities
- No differences in antibody profile (anti-dsDNA, anti-Sm, anti-Ro, anti-La, LA, aCL, anti-beta-2-glycoprotein)
LA and treatments, with vs without complications
- No differences regarding LA
- Only heparin more commonly used by women with complications
- No differences in GC or HCQ use
Safety
Pregnancy complications (miscarriage, preeclampsia/eclampsia, foetal death and/or preterm birth)
- Women with complications during pregnancy, of 809
- 114
Original publication
Pregnancy outcomes in 1869 pregnancies in a large cohort from the Spanish Society of Rheumatology Lupus Register (RELESSER). Semin Arthritis Rheum. Published 13 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →