Lupus & antiphospholipid syndrome
Hydroxychloroquine Use, Preeclampsia, and Preterm Delivery Complications in Systemic Lupus Erythematosus Pregnancies: Is There a Protective Effect?
Main finding · Preeclampsia/eclampsiaResult — go to the resultAdjusted relative risk 0.92 95% CI 0.47–1.80Authors' conclusion
Early pregnancy HCQ use in patients with SLE was not significantly associated with reduced risk of preeclampsia or preterm delivery.
Study context
- Population
- Singleton pregnancies among publicly insured women with systemic lupus erythematosus (SLE) identified before pregnancy, British Columbia Perinatal Data Registry (mean ± SD maternal age 33.1 ± 4.6 years; 43% nulliparous)597 women
- Participants
- 847 singleton pregnancies
- Exposure
- Hydroxychloroquine (HCQ) ≥2 fills or ≥60 days' supply during the first 20 weeks of pregnancy vs no fills
- Outcome
- Preeclampsia/eclampsia and preterm delivery
Methodological detailspropensity scores, modified Poisson regression, Cox proportional hazards model for preterm delivery, stratified analyses, multiple sensitivity analyses
- Propensity scores
- Modified Poisson regression
- Cox proportional hazards model for preterm delivery
- Stratified analyses
- Multiple sensitivity analyses
Main finding
Preeclampsia/eclampsia
Adjusted relative risk
0.92
95% CI 0.47–1.80
HCQvs No fills
adjusted RR 0.92 (95% CI 0.47–1.80)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Exposure window expanded to include 3 months preconception
- Results were similar
Preterm delivery
- No association across different definitions for preterm delivery
Stratified analyses (effect modification)
- No appreciable differences
Original publication
Hydroxychloroquine Use, Preeclampsia, and Preterm Delivery Complications in Systemic Lupus Erythematosus Pregnancies: Is There a Protective Effect? Arthritis Care Res (Hoboken). Published 6 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →