Lupus & antiphospholipid syndrome
Exposure to hydroxychloroquine in early pregnancy and incidence of pre-eclampsia and pre-term delivery in patients with systemic lupus erythematosus in Sweden: a nationwide population-based cohort study
Main finding · Pre-eclampsia, overallResult — go to the resultAdjusted relative risk 0.49 95% CI 0.31–0.79Authors' conclusion
In this large cohort of pregnant women with SLE, hydroxychloroquine exposure in early pregnancy was associated with a lower pre-eclampsia risk. However, the association with pre-term delivery was unclear.
Study context
- Population
- Singleton pregnancies of women with prevalent systemic lupus erythematosus (SLE) leading to delivery (livebirths and stillbirths), Sweden, 2007–2022pregnancies from 685 women
- Participants
- 959 pregnancies
- Exposure
- Hydroxychloroquine exposure in early pregnancy vs no exposure
- Outcome
- Co-primary: pre-eclampsia (from 20+0 weeks of gestation to 6 weeks postpartum) and pre-term delivery (before 37+0 weeks of gestation)
Methodological detailsinverse probability of treatment weighting, modified Poisson models, A person with lived experience of pregnancy with SLE involved in all aspects of the study
- Inverse probability of treatment weighting
- Modified Poisson models
- A person with lived experience of pregnancy with SLE involved in all aspects of the study
Main finding
Pre-eclampsia, overall
Adjusted relative risk
0.49
95% CI 0.31–0.79
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Hydroxychloroquine-exposed | Unexposed | Adjusted RR (95% CI) | |
|---|---|---|---|---|
| Pre-eclampsia, nulliparous pregnancies (subgroup) | 11% | 13% | 0.59 (0.33–1.08) | |
| Pre-eclampsia, parous pregnancies (subgroup) | 5% | 6% | 0.44 (0.22–0.89) | |
| 0.20.5125Adjusted relative risk (log scale) |
Pre-term delivery, nulliparous pregnancies (subgroup)
Pre-term delivery, parous pregnancies (subgroup)
Stratification by antiphospholipid syndrome, renal diseases and hypertension
- Similar results
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →