Lupus & antiphospholipid syndrome
A study on the evaluation of left atrial function in lupus nephritis patients using left atrial automated functional imaging technology
Authors' conclusion
The degree of LA involvement in patients with LN was significantly greater than in those with extra-renal SLE, with TG potentially serving as the only laboratory indicator capable of effectively predicting LASR.
Study context
- Population
- Patients with lupus nephritis (LN), patients with extra-renal systemic lupus erythematosus (SLE) and healthy controls undergoing routine echocardiography with AFILA
- Participants
- 79 / 91 / 42
- Exposure
- LN vs extra-renal SLE vs healthy controls
- LNn = 79
- Extra-renal SLEn = 91
- Healthy controlsn = 42reference
- Outcome
- LA strain (AFILA): LASR, LASCD, LASCT
Main finding
As reported in the abstract
| Group | Value | LASCD | LASCT |
|---|---|---|---|
| LN | 22.00% | −14.00% | −9.00% |
| Extra-renal SLE | 27.00% | −17.00% | −10.00% |
| Healthy controls | 36.00% | −24.00% | −14.00% |
Value
LN22.00%
Extra-renal SLE27.00%
Healthy controls36.00%
LASCD
LN−14.00%
Extra-renal SLE−17.00%
Healthy controls−24.00%
LASCT
LN−9.00%
Extra-renal SLE−10.00%
Healthy controls−14.00%
- LN vs Extra-renal SLE: P < 0.001 — three-group comparison of LASR, LASCD and LASCT, each p < .001; per_group value is LASR
Observational data: associations, not effects.
Further findings
Independent association of triglycerides (TG) with LASR in LN (multiple regression)
- TG β[SE]
- −1.025 [0.370], p = .007
- TG the sole laboratory indicator independently associated with LASR
Original publication
A study on the evaluation of left atrial function in lupus nephritis patients using left atrial automated functional imaging technology. Lupus. Published 10 June 2025. doi:10.
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