Lupus & antiphospholipid syndrome
A case–control study on autoimmune polyendocrine syndromes in patients with systemic lupus erythematosus
Authors' conclusion
The prevalence of autoimmune polyendocrine syndrome among SLE patients is significantly higher than in the general population (11% vs 0.005%), confirming the association between autoimmune thyroiditis and SLE. However, autoimmune polyendocrine syndrome-positive patients do not appear to have a more aggressive disease or develop more complications.
Study context
- Population
- SLE patients (SLICC 2012 and/or EULAR/ACR 2019 criteria) referred to one centre between 2021 and 2023clinical charts analysed
- Participants
- 417 patients
- Comparison
- SLE with autoimmune polyendocrine syndrome vs SLE without autoimmune polyendocrine syndrome
- Autoimmune polyendocrine syndrome-positiven = 47
- Autoimmune polyendocrine syndrome-free SLEn = 185reference
- Outcome
- Prevalence of autoimmune polyendocrine syndromes in SLE
Methodological detailssingle-centre, randomly enrolled controls
- Single-centre
- Randomly enrolled controls
Main finding
As reported in the abstract
Prevalence of autoimmune polyendocrine syndrome
APS-POSITIVE
11%
47 events
- Hashimoto thyroiditis
- 39
- Graves' disease
- 6
- Type 1 diabetes mellitus
- 3
- Autoimmune polyendocrine syndrome type 3
- 45
- Autoimmune polyendocrine syndrome type 4
- 2
- Autoimmune polyendocrine syndrome types 1 or 2
- 0
Further findings
Clinical and serological features
- No significant differences between APS-positive and APS-negative patients
Clinical remission at last evaluation
- ∼80% of both groups in clinical remission; approximately half remained on steroid therapy
SLICC Damage Index (SDI), median
- Slightly higher median SDI in APS-positive patients, not associated with increased disease activity
Original publication
A case–control study on autoimmune polyendocrine syndromes in patients with systemic lupus erythematosus. Rheumatology (Oxford). Published 10 June 2025. doi:10.
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