Lupus & antiphospholipid syndrome
Thirty-year trajectory of organ damage accrual and damage-free survival in Colombian patients with systemic lupus erythematosus: A registry-based retrospective follow-up study
Authors' conclusion
The trajectory of organ damage accrual underscores the long-term burden of SLE and the need for comprehensive interventions, particularly in patients with high-risk clinical features.
Study context
- Population
- Colombian patients aged ≥18 years with systemic lupus erythematosus (SLE) (2012 SLICC criteria) in the ARTMEDICA program, treated March 2011–August 2017mean follow-up 14.7 years
- Participants
- 559 patients
- Outcome
- Organ damage accrual (SLICC/ACR DI) and damage-free survival
Methodological detailsregistry-based, multilevel generalized linear models, parametric survival models for interval-censored data
- Registry-based
- Multilevel generalized linear models
- Parametric survival models for interval-censored data
Main finding
As reported in the abstract
Organ damage accrual and DFS
Mean SLICC/ACR Damage Index (SDI) at 15 years
1.24
95% CI 1.08–1.40
Mean SDI at 30 years
1.53
95% CI 1.16–1.90
Median organ damage-free survival (DFS), years
7.2
95% CI 5.8–8.5
Observational data: associations, not effects.
Further findings
Factors associated with faster damage accrual (mean annual change ratios (MACR) in SDI)
- Myelopathy, MACR
- 2.24; 95%CI 1.26-3.98
- Cellular casts, MACR
- 2.15; 95%CI 1.09-4.22
- Seizures, MACR
- 1.82; 1.30-2.55
- Disease activity, MACR
- 1.22; 95%CI 1.10-1.35
Relapses
- Median number of relapses
- 3.5 (IQR: 1-8)
Original publication
Thirty-year trajectory of organ damage accrual and damage-free survival in Colombian patients with systemic lupus erythematosus: A registry-based retrospective follow-up study. Lupus. Published 29 October 2025. doi:10.
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