Lupus & antiphospholipid syndrome
A randomized controlled trial of a lifestyle intervention on wellbeing in patients with systemic lupus erythematosus: Results from “Living well with lupus”
Authors' conclusion
The LWWL intervention improved fatigue and the role physical domain of quality of life in SLE patients with high cardiovascular risk.
Study context
- Population
- Adults with systemic lupus erythematosus (SLE) and high cardiovascular risk, São Paulo, Brazil, August 2020 to March 2023
- Participants
- 80 adults
- Comparison
- Living Well with Lupus (LWWL) healthy lifestyle intervention vs standard care
Methodological detailsparallel-group, 6-month
- Parallel-group
- 6-month
Further findings
| Outcome | EMD (95% CI) | P value |
|---|---|---|
| SF-36 role physical domain · post-interventionES −1.03 (95% CI −1.6; −0.4); in favour of LWWL | −1.0 (−1.6 to −0.4) | P = 0.01 |
| FACIT fatigue score · post-interventionES 1.24 (95% CI 0.5; 2.0); in favour of LWWL | 7.1 (1.6–12.6) | P = 0.01 |
Other wellbeing variables (other SF-36 domains, functional capacity, anxiety and depression symptoms, sleep quality) · post-intervention
- No significant between-group differences (p > .05)
Complete-case sensitivity analyses
- Corroborated findings; suggested improvements in mood and strength after the programme
Original publication
A randomized controlled trial of a lifestyle intervention on wellbeing in patients with systemic lupus erythematosus: Results from “Living well with lupus”. Lupus. Published 30 October 2025. doi:10.
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