Lupus & antiphospholipid syndrome
Detection rate, demographic associations and clinical implications of anti-C1q antibody elevations across diverse disease states
Authors' conclusion
Elevations in anti-C1q levels extend beyond SLE and are influenced by both demographic factors and specific disease phenotypes. Male sex and younger age emerged as significant predictors of abnormal anti-C1q status.
Study context
- Population
- Patients who underwent anti-C1q testing at one hospital, September 2020 to September 2023, 67 distinct diagnoses67 distinct diagnoses
- Participants
- 15,363 patients
- Outcome
- Detection rate of abnormal anti-C1q levels (>10 U/mL) by sex, age and diagnosis
Methodological detailssingle-centre, one-way and two-way fixed-effect models, multivariate logistic regression
- Single-centre
- One-way and two-way fixed-effect models
- Multivariate logistic regression
Main finding
As reported in the abstract
Abnormal anti-C1q levels (>10 U/mL), overall detection rate
- Abnormal anti-C1q levels, all patients
- 7.88%
- SLE without severe complications
- 853 of 3760, 22.69%
- LN
- 88 of 294, 29.93%
- Autoimmune cirrhosis
- 7 of 59, 11.86%
- SSc
- 19 of 165, 11.52%
Observational data: associations, not effects.
Further findings
Lupus manifestations and anti-C1q levels
- Lupus haematological and encephalopathic manifestations associated with elevated antibody levels
Original publication
Detection rate, demographic associations and clinical implications of anti-C1q antibody elevations across diverse disease states. Lupus Sci Med. Published 29 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →