Lupus & antiphospholipid syndrome
Unveiling the molecular and immune heterogeneity across distinct disease activity states of systemic lupus erythematosus through integrative bulk and single-cell transcriptomics
Authors' conclusion
This study unveils the profound immunological and transcriptomic dysregulation underlying SLE severity.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients stratified into SLE Disease Activity Index (SLEDAI)-defined disease states (bulk and single-cell RNA sequencing datasets)
- Comparison
- High-activity/severe SLE vs low-activity/mild SLE
- Outcome
- Molecular and immune differences across SLEDAI-defined disease states
Methodological detailsintegrative bulk and single-cell RNA sequencing, independent validation cohort
- Integrative bulk and single-cell RNA sequencing
- Independent validation cohort
Main finding
As reported in the abstract
Inferred cell–cell interactions, sSLE vs mSLE
311 vs 283
Original publication
Unveiling the molecular and immune heterogeneity across distinct disease activity states of systemic lupus erythematosus through integrative bulk and single-cell transcriptomics. Lupus Sci Med. Published 12 September 2026. doi:10.
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