Lupus & antiphospholipid syndrome
Temporal Trends and Demographic Insights Into Mortality From Systemic Lupus Erythematosus, 1999–2020
Authors' conclusion
Since 1999, SLE-related mortality rates have consistently declined across various demographic groups, though rates remain disproportionately high in African American participants, particularly among African American female participants and in Southern states.
Study context
- Population
- Systemic lupus erythematosus (SLE) deaths in the United States, 1999–2020deaths with SLE as underlying cause
- Participants
- 27,213 deaths
- Exposure
- AAMR by sex, race and ethnicity, and state
- Outcome
- Age-adjusted mortality rates (AAMRs) from SLE
Methodological detailsCDC WONDER Multiple Cause of Death database, simple linear regression of trends
- CDC WONDER Multiple Cause of Death database
- Simple linear regression of trends
Main finding
As reported in the abstract
SLE AAMR · 1999–2020
- Significant decline in SLE AAMR from 1999 to 2020, across all demographic groups (R2)
- 0.902
Observational data: associations, not effects.
Further findings
- SLE AAMR in African American female participants · female subgroup — African American
- 17.68 (95% CI 17.29–18.06) per million
SLE AAMR to non-SLE AAMR ratio · 2005 to 2020
- Sustained decline (R2)
- 0.8552
Geographic distribution of SLE AAMR
- Pronounced concentration in Southern states
Original publication
Temporal Trends and Demographic Insights Into Mortality From Systemic Lupus Erythematosus, 1999–2020. Arthritis Care Res (Hoboken). Published 7 March 2025. doi:10.
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