Characterizing lupus in African American children in Southern United States
Authors' conclusion
Compared to previously described multiethnic cohorts of cSLE, this predominantly AA patient population in the Southern United States has significantly higher disease activity and greater damage accrual. Social risk factors for this population include a higher SVI, longer distance from an academic pediatric rheumatology center, and having Medicaid insurance.
Study context
- Population
- Patients with childhood SLE (childhood systemic lupus erythematous (cSLE)) at two centres (University of Mississippi Medical Center (UMMC) and UAB) in the Black Belt of the Southeastern United States82.2% AA
- Participants
- 45 patients
- Outcome
- Clinical, demographic and socioeconomic profile of cSLE
Methodological detailstwo-centre, retrospective chart review
- Two-centre
- Retrospective chart review
Main finding
As reported in the abstract
- Female
- 82.2%
- AA ethnicity
- 82.2%
- Medicaid insurance
- 66.7%
- Mean age at diagnosis, years (+/- 2.8)
- 13.5
- Mean American College of Rheumatology (ACR) score at diagnosis (+/- 1.27)
- 5.1
- SLICC score (+/- 2.5)
- 8.4
- Average baseline Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) (+/- 9.3)
- 13.06
- SLEDAI at 6 months
- 7.4
- SLEDAI at 1 year
- 4.7
- Average distance traveled to see a rheumatologist, miles (national average 42.8 miles)
- 74.83
- Medium-high or high Social Vulnerability Index (SVI) group based on zip code (37/45)
- 82%
Observational data: associations, not effects.
Original publication
Characterizing lupus in African American children in Southern United States. Pediatr Rheumatol Online J. Published 7 April 2025. doi:10.
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