Serositis as an indicator of poor prognosis in pediatric systemic lupus erythematosus
Main finding · All-cause mortalityResult — go to the resultHazard ratio 5.585 CI 1.853–17.80Authors' conclusion
Children with lupus serositis had higher disease activity, a higher prevalence of comorbidities, and mortality. Patients with both serositis, especially late-onset serositis, and ESRD had an increased risk of poor long-term survival.
Study context
- Population
- Patients with childhood-onset systemic lupus erythematosus (SLE) (cSLE) at a medical center in Taiwan, January 2002 to December 2022
- Participants
- 185 patients
- Exposure
- cSLE with serositis vs without serositis
- Serositisn = 38
- Outcome
- All-cause mortality
Methodological detailssingle-centre, multivariate Cox regression
- Single-centre
- Multivariate Cox regression
Main finding
As reported in the abstract
Hazard ratio
5.585
CI 1.853–17.80
Serositisvs Without serositis
HR 5.585 (CI 1.853–17.80)
Observational data: associations, not effects.
Further findings
- Prevalence of serositis in cSLE
- 20.54% · 38
All-cause mortality associated with end-stage renal disease (ESRD)
- ESRD associated with mortality risk (multivariate Cox regression), HR
- 13.956; CI: 3.822-50.964
Clinical features, serositis vs without serositis
- Serositis: younger age at SLE diagnosis, higher SLEDAI-2K at serositis diagnosis, more LN, CNS manifestations and ESRD, higher Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) DI and higher mortality
20-year survival (Kaplan-Meier)
- Poorest survival in patients with both serositis and ESRD
Mortality, late-onset vs early-onset serositis
- Late-onset serositis (1 year after SLE diagnosis) had higher mortality rates than early-onset
Original publication
Serositis as an indicator of poor prognosis in pediatric systemic lupus erythematosus. Pediatr Rheumatol Online J. Published 1 April 2025. doi:10.
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