Level of CD4 + central memory T cells and its clinical correlation in childhood-onset systemic lupus erythematosus
Authors' conclusion
CD4+ TCM likely plays a central immune regulatory role in cSLE, with its levels closely associated with disease activity, specific autoantibody production, and early organ damage.
Study context
- Population
- Children with newly diagnosed, untreated rheumatic diseases and healthy controls
- Participants
- 64 / 71 / 31 / 36 / 22
- Exposure
- cSLE vs other pediatric rheumatic diseases and healthy controls
- cSLEn = 64
- JIAn = 71
- JDMn = 31
- Autoinflammatory diseasesn = 36
- Healthy controlsn = 22reference
- Outcome
- CD4+ TCM levels in cSLE and their association with disease activity, clinical features and treatment responses
Methodological detailsmulti-color flow cytometry, longitudinal follow-up subset
- Multi-color flow cytometry
- Longitudinal follow-up subset
Main finding
As reported in the abstract
Proportion of CD4+ TCM
cSLE
44.3
± 11.5 · %
P < 0.05
- Correlation with SLEDAI-2000 score
- r = −0.255, p = .021
- Correlation with oral ulcers
- r = −0.285, p = .011
- Correlation with leukopenia
- r = 0.302, p = .008
- Correlation with anti-dsDNA
- r = −0.294, p = .009
- Correlation with anti-histone antibodies
- r = −0.232, p = .033
- Correlation with anti-Sm antibodies
- r = 0.245, p = .025
- Correlation with urinary transferrin
- r = −0.315, p = .008
- Correlation with urinary microalbumin
- r = −0.284, p = .015
- Correlation with CD4+ Naive cells
- r = −0.831, p < .001
- Correlation with IFN-α levels
- r = −0.364, p = .031
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Longitudinal CD4+ TCM levels post-treatmentCYC-treated vs Non-CYC · significantly increased CD4+ TCM with CYC | P = 0.034 |
Longitudinal CD4+ TCM levels post-treatment
- Time-dependent biphasic pattern in CD4+ TCM levels
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Level of CD4 + central memory T cells and its clinical correlation in childhood-onset systemic lupus erythematosus. Lupus. Published 4 August 2025. doi:10.
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