Prognostic factors for disease progression and mortality of childhood-onset lupus nephritis in the Philippines: a retrospective cohort study in a tertiary hospital
Authors' conclusion
Childhood-onset LN remains associated with high morbidity and mortality in the Philippines
Study context
- Population
- Patients under 19 years diagnosed with lupus nephritis (LN), January 2014 to December 2021, Philippine General Hospital (tertiary hospital)female-to-male ratio 13.2:1
- Participants
- 128 participants
- Outcome
- Predictors of mortality and progression to CKD 5
Methodological detailssingle-centre, Kaplan-Meier survival, Cox proportional hazards regression, logistic regression
- Single-centre
- Kaplan-Meier survival
- Cox proportional hazards regression
- Logistic regression
Main finding
As reported in the abstract
Predictors of poor health outcomes:
- Mortality
- Progression to CKD 5
Nephrotic range proteinuria, HR
2.91
Hypertension at diagnosis, OR
5.57
Failure to achieve early partial response or complete remission, HR
3.69
Observational data: associations, not effects.
Further findings
Mortality during observation period · median follow-up 2.2 years (range, 0.0-8.8 years)
- Patients who died
- 25 (19.5%)
- Leading cause of mortality: infection
Kidney biopsy performed
- Underwent kidney biopsy, mainly due to financial constraints
- 16%
Treatment delays and poor adherence
- Treatment delays
- 60%
- Poor adherence
- 38%
- Largely due to financial hardship and limited healthcare access
Original publication
Prognostic factors for disease progression and mortality of childhood-onset lupus nephritis in the Philippines: a retrospective cohort study in a tertiary hospital. Pediatr Rheumatol Online J. Published 2 August 2025. doi:10.
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