Lupus & antiphospholipid syndrome

Association Between Race/Ethnicity and COVID‐19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID‐19 Global Rheumatology Alliance

Arthritis Care Res (Hoboken)Published Registry-based cohort study

Authors' conclusion

Black and Hispanic individuals with SLE experienced more severe COVID-19 outcomes, which is consistent with findings in the US general population.

Study context

Population
Individuals with systemic lupus erythematosus (SLE) from the US entered into the COVID-19 Global Rheumatology Alliance registry, March 24, 2020 to August 27, 2021473 (90.4%) female
Participants
523 individuals
Exposure
Black, Hispanic and other race/ethnicity vs White individuals with SLE
Outcome
COVID-19 severity (ordinal: not hospitalized, hospitalized with no oxygenation, hospitalized with any ventilation or oxygenation, death)
Methodological detailsCOVID-19 Global Rheumatology Alliance registry, multivariable ordinal logistic regression
  • COVID-19 Global Rheumatology Alliance registry
  • Multivariable ordinal logistic regression

Main finding

As reported in the abstract

Odds of more severe COVID-19 outcomes (multivariable model)
Each group vs whiteOdds ratio (95% CI)
Black
2.73(1.36–5.53)
Hispanic
2.76(1.34–5.69)

Observational data: associations, not effects.

Further findings

COVID-19 outcome distribution, all patients

Not hospitalized
358 (74.6%)
Hospitalized without oxygen
40 (8.3%)
Hospitalized with any oxygenation
64 (13.3%)
Died
18 (3.8%)

Original publication

Association Between Race/Ethnicity and COVID‐19 Outcomes in Systemic Lupus Erythematosus Patients From the United States: Data From the COVID‐19 Global Rheumatology Alliance. Arthritis Care Res (Hoboken). Published 2 December 2022. doi:10.1002/acr.25039

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