Lupus & antiphospholipid syndrome
Depressed Symptomatology in Systemic Lupus Erythematosus Patients
Authors' conclusion
The majority (61.2%) of patients had CESD-R scores consistent with persistent depressed affect or major depression over a period of up to 4 years.
Study context
- Population
- Outpatients with ACR- or SLICC-classified systemic lupus erythematosus (SLE), longitudinal SLE cohort at the Washington University Lupus Clinic56.3% Black, 38.9% White
- Participants
- 144 outpatients
- Exposure
- Groups 4 vs 5
- Groups 4n = 44
- 5n = 44
- Outcome
- Longitudinal course of depressed affect (CESD-R) and its relationship with SLE disease activity (SLEDAI-2K)
Methodological detailsgroup-based trajectory modelling, linear mixed models
- Group-based trajectory modelling
- Linear mixed models
Main finding
As reported in the abstract
Depression trajectories (CESD-R) by GBTM · up to 4 years
- Patients with CESD-R scores consistent with persistent depressed affect or major depression
- 61.2%
Observational data: associations, not effects.
Further findings
- Black patients in group 5
- 72.7% · 32 of 44
- Black patients in group 5: P < 0.02
Association between SLEDAI disease activity and depression scores
- Association in multivariate analysis but not significant in group-based trajectory modeling (GBTM) and univariate analysis
Original publication
Depressed Symptomatology in Systemic Lupus Erythematosus Patients. Arthritis Care Res (Hoboken). Published 2 December 2022. doi:10.
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