Lupus & antiphospholipid syndrome
Genome-wide methylation profiling identifies signatures of pain, fatigue and health scores in women with systemic lupus erythematosus
Authors' conclusion
By studying a cohort of women with well-controlled SLE, we identified several CpGs and genes associated with pain, fatigue and general health.
Study context
- Population
- Women with systemic lupus erythematosus (SLE) from the SLEGOT cohort with low disease activity (median SLEDAI-2K = 0) and minimal damage (median SLICC damage index = 0)
- Participants
- 48 women
- Outcome
- Epigenetic alterations (DNA methylation) associated with self-reported pain, fatigue and health scores
Methodological detailscohort (SLEGOT), whole blood
- Cohort (SLEGOT)
- Whole blood
Main finding
As reported in the abstract
Differentially methylated CpGs linked to pain, fatigue and poor health
Differentially methylated CpGs linked to pain
485
Differentially methylated CpGs linked to fatigue
591
Differentially methylated CpGs linked to poor health
577
Genes, incl. BDNF and TGIF1, strongly correlated with all three scores
9
Observational data: associations, not effects.
Original publication
Genome-wide methylation profiling identifies signatures of pain, fatigue and health scores in women with systemic lupus erythematosus. Rheumatology (Oxford). Published 30 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →