Lupus & antiphospholipid syndrome
Untargeted breathomics identifies metabolic signatures of immune activity, intestinal integrity, and fatigue in systemic lupus erythematosus
Authors' conclusion
VOC signatures reflected immunometabolic perturbations, oxidative stress, and gut barrier integrity.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and matched healthy controls
- Participants
- 30 vs 30
- Exposure
- SLE patients vs matched healthy controls
- SLEn = 30
- Healthy controlsn = 30reference
- Outcome
- Breath metabolome (VOCs) in SLE and associations with clinical features, incl. disease activity and fatigue
Methodological detailsmatched healthy controls, untargeted breathomics (thermal desorption GC-MS), Exhaled breath collected with ReCIVA Breath Sampler; Volatile organic compounds (VOCs) identified with high-resolution libraries and classified by confidence levels
- Matched healthy controls
- Untargeted breathomics (thermal desorption GC-MS)
- Exhaled breath collected with ReCIVA Breath Sampler; VOCs identified with high-resolution libraries and classified by confidence levels
Main finding
As reported in the abstract
Breath VOCs
Detected VOCs
1433
VOCs with levels over background (breath-derived)
539
VOC clusters identified
5
Observational data: associations, not effects.
Original publication
Untargeted breathomics identifies metabolic signatures of immune activity, intestinal integrity, and fatigue in systemic lupus erythematosus. Ann Rheum Dis. Published 2 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →