Lupus & antiphospholipid syndrome
Associations between TCA cycle plasma metabolites and fatigue in black females with systemic lupus erythematosus: An untargeted metabolomics pilot study
Authors' conclusion
While pervasive perturbations in the entire TCA cycle have been implicated as a potential mechanism for fatigue, our results suggest individual metabolites of AKG and succinate may be potential biomarkers or targets of intervention for fatigue symptom management in SLE.
Study context
- Population
- Black females with systemic lupus erythematosus (SLE) and no SLE controls
- Participants
- 23 vs 21
- Exposure
- Black females with SLE vs no SLE controls
- SLEn = 23
- No SLEn = 21reference
- Outcome
- Plasma metabolites associated with SLE-related fatigue (Multidimensional Fatigue Inventory (MFI): general, physical, mental fatigue, reduced activity, reduced motivation)
Methodological detailspilot study, untargeted metabolomics, ultrahigh performance liquid chromatography/tandem mass spectrometry
- Pilot study
- Untargeted metabolomics
- Ultrahigh performance liquid chromatography/tandem mass spectrometry
Main finding
As reported in the abstract
- Metabolites significantly different between SLE and no SLE (glycolysis, TCA cycle, heme catabolism, branched chain amino acids, fatty acid metabolism, steroids)
- 290
- Within SLE, adjusted for age and co-morbidities, TCA cycle metabolites alpha-ketoglutarate (AKG) and succinate significantly associated with physical and general fatigue
- p < .05
Observational data: associations, not effects.
Original publication
Associations between TCA cycle plasma metabolites and fatigue in black females with systemic lupus erythematosus: An untargeted metabolomics pilot study. Lupus. Published 17 June 2024. doi:10.
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