Lupus & antiphospholipid syndrome
Addition of constitutional symptoms to the SLEDAI-2K improves overall disease activity assessment: A pilot study
Authors' conclusion
The addition of constitutional symptoms to SLEDAI-2K, particularly fatigue, resulted in a marginal increase in its correlation with PGA, and new constitutional symptoms associated with higher SLED-O and PGA scores.
Study context
- Population
- Patients with SLE1,123 assessments
- Participants
- 239 patients
- Comparison
- Revised SLEDAI-2K with constitutional descriptor (SLED-R) vs original SLEDAI-2K (SLED-O), PGA as reference
- Outcome
- Concurrent and construct validity: correlation with PGA
Methodological detailspilot study, repeated measures
- Pilot study
- Repeated measures
Performance
As reported in the abstract
Correlation with PGA
- Fatigue contributed most to this increase
- p = .001
Further findings
Frequency of scoring: constitutional descriptor vs fever descriptor · subjects scored
Instances SLED-R 92 (8.1%) · SLED-O 5 (0.4%)
Disease activity scores when constitutional descriptor scored vs not
- Mean SLED-O, PGA and PtGA scores higher when constitutional descriptor scored
- P < 0.001
- Fatigue associated with higher PGA and PtGA scores
- P < 0.001
- Mean SLED-O and PGA higher when ≥1 constitutional symptom(s) scored
- P < 0.002
PGA–PtGA correlation and concordance by new descriptor
- Correlations between PGA and PtGA similar when new descriptor scored vs not
- P = 0.860
- Concordance PGA–PtGA when new descriptor scored
- 55%
- Concordance PGA–PtGA when new descriptor not scored
- 72.5%
- PGA > PtGA when new descriptor scored
- P < 0.001
Original publication
Addition of constitutional symptoms to the SLEDAI-2K improves overall disease activity assessment: A pilot study. Lupus. Published 25 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →