Lupus & antiphospholipid syndrome
Risk stratification for infection during immunosuppressive therapy in patients with lupus nephritis: A nested case-control study
Authors' conclusion
A risk stratification was built to predict the risk of infection in patients with LN undergoing immunosuppressive therapy.
Study context
- Population
- Patients with lupus nephritis (LN) treated with immunosuppressive therapy, 2014–2022, Nephrology ward, Huashan Hospital (Fudan University) and Huashan Hospital Baoshan Branch1:3 nested matching
- Participants
- 53 vs 159
- Comparison
- Patients with infection (cases) vs patients without infection (controls) during immunosuppressive therapy for LN
- Casesn = 53
- Controlsn = 159reference
- Outcome
- Infection during immunosuppressive therapy (risk stratification)
Methodological detailsretrospective, 1:3 nested matching, multivariable logistic regression, internal random sampling validation
- Retrospective
- 1:3 nested matching
- Multivariable logistic regression
- Internal random sampling validation
Main finding
As reported in the abstract
Factors independently associated with infection (multivariable logistic regression)
Odds ratio (95% CI)P value
Change rate of fibrinogen
0.97(0.94–0.99)
P = 0.008Leukopenia
8.68(1.16–301.72)
P = 0.039Reduced albumin
6.25(1.38–28.24)
P = 0.017Observational data: associations, not effects.
Further findings
Model discrimination (AUC of ROC curve, validation set, internal random sampling)
- AUC
- 0.864
Infection risk stratification (scores range from −2 to 10)
- Infection risk at score −2
- 2.8%
- Infection risk at score 10
- 97.5%
Original publication
Risk stratification for infection during immunosuppressive therapy in patients with lupus nephritis: A nested case-control study. Lupus. Published 25 April 2024. doi:10.
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