Lupus & antiphospholipid syndrome
Temporal trends in mortality in patients with systemic lupus erythematosus: a Danish population-based matched cohort study
Authors' conclusion
The 5-year mortality risk decreased over time for both patients with SLE and matched controls. However, excess 5-year mortality for patients with SLE in the most recent calendar period and excess mortality late in their disease course remained.
Study context
- Population
- Incident SLE cases diagnosed 1996–2015 in Danish administrative health registries, followed until 2020, and matched general population controlsmatched cohort
- Participants
- 1,351 vs 6,755
- Exposure
- SLE vs matched general population controls
- SLEn = 1,351
- Controlsn = 6,755reference
- Outcome
- All-cause mortality
- Follow-up
- 5 and 10 years
Methodological detailsnationwide, exposure-matched 1:5 on age and sex, pseudo-observation approach
- Nationwide
- Exposure-matched 1:5 on age and sex
- Pseudo-observation approach
Main finding
As reported in the abstract
5-year mortality, crude RD over the study period · 5 years
Crude risk difference (RD), start of study period
10.3%
95% CI 6.5–14.1%
SLE
Crude RD, end of study period
4.6%
95% CI 1.4–7.8%
SLE
Observational data: associations, not effects.
Further findings
10-year mortality
- Crude and adjusted RD and RR did not change over the calendar period
- 10-year RR highest in young patients with SLE (<50 years of age)
Original publication
Temporal trends in mortality in patients with systemic lupus erythematosus: a Danish population-based matched cohort study. Rheumatology (Oxford). Published 24 April 2024. doi:10.
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