Lupus & antiphospholipid syndrome
Age‐Specific Incidence of Systemic Lupus Erythematosus in the United States: A Meta‐Analysis of Data From the Centers for Disease Control and Prevention Lupus Registries
Authors' conclusion
This study provides comprehensive sex- and race-specific estimates of age at SLE diagnosis.
Study context
- Population
- People with systemic lupus erythematosus (SLE) fulfilling ACR classification criteria in CDC population-based lupus registries, United States, 2002–2018five state-based registries plus a sixth IHS registry
- Outcome
- Age-specific incidence of SLE per 100,000 person-years, by sex, race and ethnicity
Methodological detailsCDC National Lupus Registry network, five state-based registries plus an Indian Health Service registry, stratified by sex, race and ethnicity
- CDC National Lupus Registry network
- Five state-based registries plus an Indian Health Service registry
- Stratified by sex, race and ethnicity
Pooled result
As reported in the abstract
Age-specific SLE incidence per 100,000 person-years
- Women: highest incidence at age 30–39 years
- 12.7 (95% CI 9.5-16.8)
- Men: highest incidence at age 60–69 years
- 2.1 (95% CI 1.3-3.4)
- Black women aged 20–39 years: highest SLE incidence
- 23.6 (95% CI 20.7-26.8)
- Women diagnosed before age 20 years: highest among Asian individuals
- 6.5 (95% CI 2.8-15.2)
- Women diagnosed after age 60 years: highest among American Indian/Alaska Native individuals
- 9.4 (95% CI 3.4-15.4)
Further pooled results
Weighted percentage by age at SLE diagnosis
- Diagnosed before age 20 years
- 10.0%
- Diagnosed after age 60 years
- 15.1%
- Diagnosed between ages 30 and 39 years (largest proportion)
- 22.1%
Original publication
Age‐Specific Incidence of Systemic Lupus Erythematosus in the United States: A Meta‐Analysis of Data From the Centers for Disease Control and Prevention Lupus Registries. Arthritis Rheumatol. Published 24 August 2026. doi:10.
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