Lupus & antiphospholipid syndrome
Clinical characteristics of patients with late-onset systemic lupus erythematosus with a disease onset of ≤ 3 months
Authors' conclusion
Patients with very early-stage late-onset SLE exhibited distinct clinical and serological features. However, their disease activity was essentially consistent with that of early-onset SLE, and they often require intensive immunosuppressive therapy.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) whose disease onset was ≤3 months
- Participants
- 145 patients
- Exposure
- Late-onset SLE vs early-onset SLE
- Late-onset SLEn = 31
- Early-onset SLEn = 114reference
- Outcome
- Clinical characteristics at initial stage of onset
Further findings
Rash prevalence
P = 0.040
Anti-dsDNA antibody positivity
P = 0.027
Pericarditis
P = 0.047
C3 levels
P = 0.018
| Outcome | Late-onset SLE | Early-onset SLE | P value |
|---|---|---|---|
| SLEDAI 2000 | 10 (interval 8–20) | 15 (interval 10–22) | P = 0.066 |
| SLE-DASSimilar between the groups | 13.33 (interval 11.50–28.45) | 15.48 (interval 8.56–25.18) | P = 0.744 |
High-dose or IV pulse corticosteroid therapy
- More than half of late-onset SLE patients; no statistically significant difference vs early-onset SLE
Original publication
Clinical characteristics of patients with late-onset systemic lupus erythematosus with a disease onset of ≤ 3 months. Lupus. Published 24 August 2026. doi:10.
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