Lupus & antiphospholipid syndrome
Mental health conditions in patients with systemic lupus erythematosus: a systematic review and meta-analysis
Authors' conclusion
Our study demonstrated a high prevalence of MHCs among patients with SLE. Individuals with pre-existing mental disorders exhibited an elevated susceptibility to developing SLE and patients presenting with MHCs were at increased risk of experiencing suboptimal health and functional outcomes.
Study context
- Population
- People with systemic lupus erythematosus (SLE); studies published before June 2023 (PubMed, Web of Science, Embase)
- Participants
- 1,485,094 people203 studies
- Outcome
- Pooled prevalence of MHCs in SLE and association of MHCs with risk of SLE and patient outcomes
Methodological detailsumbrella and updated meta-analysis, random-effect models
- Umbrella and updated meta-analysis
- Random-effect models
Pooled result
As reported in the abstract
Sleep disturbance among adults with SLE (most common MHC), pooled prevalence
59.7%
95% CI 52.4–66.8%
Cognitive dysfunction among children with SLE (most common MHC), pooled prevalence
63.4%
95% CI 46.9–77.9%
Further pooled results
Risk of developing SLE in general population with mental health conditions (MHCs)
| RR (95% CI) | ||
|---|---|---|
| Depressive disorders | 2.30 (1.94–2.75) | |
| Posttraumatic stress disorder | 1.93 (1.61–2.31) | |
| 0.20.5125Relative risk (log scale) |
Outcomes in SLE with concurrent MHCs
- Concurrent MHCs linked to decreased quality of life, increased risk of unemployment and other somatic comorbidities
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →