Lupus & antiphospholipid syndrome
Anti-phosphatidylserine/prothrombin antibodies in antiphospholipid syndrome: clinical associations and methodological heterogeneity—a scoping review
Authors' conclusion
aPS/PT antibodies show a reproducible clinical and laboratory signal across the APS spectrum, but their immediate value is most likely as a selective adjunct in diagnostically challenging settings rather than as a universal fourth criterion antibody. Prospective multicentre studies using harmonized assays must establish whether aPS/PT provides independent diagnostic or prognostic information beyond LA and conventional aPL profiles.
Study context
- Population
- Human studies published from January 2000 onward that evaluated aPS/PT antibodies in antiphospholipid syndrome (APS) or seronegative APS (SN-APS); PubMed, Embase, Scopus, and Web of Sciencestudies included
- Participants
- 58 studies
- Outcome
- Association of aPS/PT with thrombosis
Methodological detailsprospectively registered, in accordance with PRISMA-ScR, synthesized descriptively
- Prospectively registered
- In accordance with PRISMA-ScR
- Synthesized descriptively
Main finding
As reported in the abstract
Studies evaluating association with thrombosis
36
Of those, studies reporting a positive relationship
32
Further findings
Association of aPS/PT with pregnancy morbidity
- Studies assessing pregnancy morbidity
- 36
- Of those, studies reporting a positive association
- 21
- Outcome definitions were highly variable
Association between aPS/PT and lupus anticoagulant (LA)
- Studies reporting a positive relationship
- 31 of 35
- The most consistent laboratory finding
Studies in SN-APS
- Studies including patients with SN-APS
- Twenty-two
- Of those, studies specifically examining aPS/PT in this population
- six
Assay methodology
- Studies using commercial assays (predominantly ELISA)
- 42
- Studies assessing persistence at least 12 weeks apart
- 11
- Cut-off selection, titre reporting, and confirmation of persistence varied substantially
Original publication
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