Lupus & antiphospholipid syndrome
Factors associated with medication adherence among patients with systemic lupus erythematosus: A systematic review
Authors' conclusion
Medication adherence in patients with SLE reflects the combined influence of structural inequalities and modifiable mediators.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE); observational or qualitative studies published 2000–2020 (PubMed, Scopus, Web of Science)
- Participants
- 200,807 patients24 studies
- Outcome
- Factors associated with medication adherence in SLE
Methodological detailsnarrative synthesis, PRISMA 2020, meta-analysis not feasible due to heterogeneity
- Narrative synthesis
- PRISMA 2020
- Meta-analysis not feasible due to heterogeneity
Pooled result
As reported in the abstract
Factors associated with non-adherence / adherence
- Very low or low socioeconomic status, non-adherence: OR
- 2.6 (95% CI 1.6-4.3)
- Living in rural areas, non-adherence: OR
- 3.4 (95% CI 1.4-5.0)
- Racial residential segregation, adherence: OR
- 0.80 (95% CI 0.67-0.96)
- Structural disadvantages linked to impaired provider-patient communication: β (p < .001)
- −0.41
- Impaired communication weakened trust in treatment: γ
- 0.68
- Trust in treatment as mediator of adherence: R2
- 0.83
- Poor adherence and increased disease activity: HR
- 2.11 (95% CI 1.75-3.02)
- Poor adherence and greater psychological burden: OR
- 5.7 (95% CI 3.8-7.9)
- Each one-point decrease in MMSE: increase in missed doses
- 7.2%
Original publication
Factors associated with medication adherence among patients with systemic lupus erythematosus: A systematic review. Lupus. Published 6 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →