Lupus & antiphospholipid syndrome
Disease activity and patient‐perceived health: associations with the Patient Acceptable Symptom State (PASS) in a large multicenter systemic lupus erythematosus cohort
Authors' conclusion
DORIS remission and LLDAS are associated with PASS, supporting their relevance as treatment targets from the patient's perspective. Pain, fatigue and anxiety hinder many patients with SLE from achieving satisfactory health beyond disease remission. One in five patients in remission is still not in PASS. PASS assessment may help capture unmet needs in SLE management.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) in the Spanish multicenter SLE registry (RELESSER)patients reporting being in PASS (72% of patients)
- Participants
- 1,249 patients
- Outcome
- Being in PASS (self-reported)
Methodological detailsRELESSER, univariable and multivariable logistic regression, subgroup analysis in patients in DORIS remission
- RELESSER
- Univariable and multivariable logistic regression
- Subgroup analysis in patients in DORIS remission
Main finding
As reported in the abstract
Patients reporting being in PASS
72%
n=1249
Observational data: associations, not effects.
Further findings
Disease activity measures associated with PASS
- Lower SLEDAI-2K, DORIS remission and LLDAS were independently associated with being in PASS
Socio-demographic and clinical factors associated with PASS
- Higher education level and being employed were positively associated with PASS
- Female sex and fibromyalgia were negatively associated with PASS
Models including Lupus Impact Tracker (LIT) items
- DORIS remission and LLDAS remained associated; pain, fatigue-related limitations and anxiety showed the strongest associations
Not in PASS among patients in DORIS remission (subgroup)
- Patients in DORIS remission not in PASS
- 20%
- Female sex, fibromyalgia, pain, fatigue-related limitations and anxiety remained independent barriers
Original publication
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