Lupus & antiphospholipid syndrome
Articular involvement in antiphospholipid syndrome: Clinical, laboratory, and imaging characterization
Main finding · AgeResult — go to the resultp = 0.206Authors' conclusion
Articular manifestations are common in APS, particularly in APS/SLE, but are not consistently supported by objective evidence of inflammation. This dissociation suggests that musculoskeletal involvement may not be primarily mediated by overt inflammatory mechanisms.
Study context
- Population
- Participants aged 18–50 years with primary or systemic lupus erythematosus (SLE)-associated APS and healthy controlsparticipants aged 18–50 years
- Participants
- 99 participants
- Exposure
- Primary and systemic lupus erythematosus (SLE)-associated APS compared with healthy controls
- Primary APS (PAPS)n = 38
- APS/SLEn = 26
- Healthy controlsn = 35
- Outcome
- Age
Methodological detailsage- and sex-matched healthy controls
- Age- and sex-matched healthy controls
Main finding
As reported in the abstract
p =
0.206
Observational data: associations, not effects.
Further findings
ESR
Joint effusion on US
| Outcome | PAPS | APS/SLE | Healthy controls | P value |
|---|---|---|---|---|
| Lupus anticoagulantPAPS vs APS/SLE | 94.7% | 96.2% | — not stated in the abstract | P = 0.792 |
| IgG anticardiolipinPAPS vs APS/SLE · more frequent in PAPS | 42.1% | 15.4% | — not stated in the abstract | P = 0.024 |
| Anti-β2-glycoprotein I antibodiesPAPS vs APS/SLE · more frequent in PAPS | 32.4% | 0% | — not stated in the abstract | P = 0.019 |
| ArthralgiaAPS/SLE vs PAPS · more frequent in APS/SLE | 50% | 80.8% | — not stated in the abstract | P = 0.013 |
| Morning stiffnessAPS/SLE vs PAPS · more frequent in APS/SLE | 21.1% | 46.2% | — not stated in the abstract | P = 0.033 |
| RF positivity | 2.6% | — not stated in the abstract | — not stated in the abstract |
— not stated in the abstract
- Erythrocyte sedimentation rate (ESR): p < 0.001
- Rheumatoid factor (RF) positivity: p = 1.000
- Joint effusion on ultrasound (US): p = 0.001
C-reactive protein (CRP)
- Did not differ significantly among groups
- p = 0.118
RF positivity
- Did not differ among groups
Anti-CCP IgG antibodies
- Absent in all groups
Radiographic findings
- Mild and comparable
Synovitis, tenosynovitis, Power Doppler signal, and other US findings
- No significant differences
Original publication
Articular involvement in antiphospholipid syndrome: Clinical, laboratory, and imaging characterization. Lupus. Published 3 November 2026. doi:10.
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