Lupus & antiphospholipid syndrome
Risk and triggering factors for diffuse alveolar hemorrhage in primary antiphospholipid syndrome. An observational follow-up study and a systematic review of the literature
Authors' conclusion
Some risk factors and comorbidities characterizing PAPS-associated DAH patients were identified when the clinical and laboratory characteristics of a group of these subjects were compared with those of a control group and of PAPS-associated DAH patients pinpointed by a literature review.
Study context
- Population
- Primary APS patients fulfilling the Sydney criteria, all with thrombosis142 women and 55 men
- Participants
- 197 patients
- Comparison
- Primary antiphospholipid syndrome (PAPS)-associated diffuse alveolar hemorrhage (DAH) vs PAPS without DAH (controls); and vs PAPS-associated DAH patients from literature review
- DAHn = 8
- Literature-review DAHn = 55
- Outcome
- Risk factors and comorbidities (left-sided heart valve diseases, left HF, hemolytic anemia) associated with DAH
Methodological detailscase-control comparison, logistic regression analysis
- Case-control comparison
- Logistic regression analysis
Pooled result
As reported in the abstract
DAH
4.1 %
8
- Multiple types of vascular involvement profile, independent risk factor
- P = 0.030
- Left-sided heart valve diseases, independent risk factor
- 0.022
- Hemolytic anemia, independent risk factor
- 0.007
Further pooled results
Characteristics of DAH vs controls
- Male gender more prevalent in DAH
- P = 0.0399
- Multiple types of vascular involvement profile more prevalent in DAH
- P = 0.0048
- High aPL titers more prevalent in DAH
- P = 0.0011
- Left-sided heart valve diseases higher in DAH
- 0.0253
- Left HF higher in DAH
- 0.0451
- Hemolytic anemia higher in DAH
- 0.0358
- Triple aPL positivity and microcirculation thrombosis more frequent in DAH, not significant
DAH patients vs literature-review DAH patients
- Clinical and laboratory characteristics and comorbidities not significantly different
- Only hemolytic anemia significantly less frequent in literature-review DAH patients
- 24 studies (one case-control, three small case series, 20 case reports)
Original publication
Risk and triggering factors for diffuse alveolar hemorrhage in primary antiphospholipid syndrome. An observational follow-up study and a systematic review of the literature. Semin Arthritis Rheum. Published 25 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →