Lupus & antiphospholipid syndrome
Distinctive cerebral small vessel disease patterns are associated with ischemic stroke in systemic lupus erythematosus
Main finding · Summary CSVD score associated with IS+Result — go to the resultOdds ratio 3.83 95% CI 1.73–9.87Authors' conclusion
CSVD was more frequent in IS+ than in IS-, highlighting the need for prospective studies in SLE to test CSVD as a biomarker of IS risk. Microbleeds predominated in the cortical region, different from reports of age-related and hypertension-associated CSVD.
Study context
- Population
- SLE patients who underwent brain MRI between 2010 and 2021, academic referral center in São Paulo, Brazil (median age 41 years; 92% women)
- Participants
- 106 patients
- Exposure
- SLE with ischemic stroke vs SLE without ischemic stroke
- Ischemic stroke (IS)+n = 53
- IS-n = 53reference
- Outcome
- Summary CSVD score (microbleeds, lacunes, enlarged perivascular spaces, white matter hyperintensities) associated with IS
Methodological detailssingle-centre (academic referral center), blinded consensus neuroradiology reading, logistic regression
- Single-centre (academic referral center)
- Blinded consensus neuroradiology reading
- Logistic regression
Main finding
Summary CSVD score associated with IS+
Odds ratio
3.83
95% CI 1.73–9.87
P = 0.002
IS+vs IS-
OR 3.83 (95% CI 1.73–9.87); P = 0.002
As reported in the abstract
Observational data: associations, not effects.
Further findings
Location of cerebral small vessel disease (CSVD) lesions
- Microbleeds in cortical regions
- 23/24, 92%
- Lacunes in basal ganglia
- 10/16, 63%
- White matter hyperintensities in deep white matter
- 47/59, 80%
Original publication
Distinctive cerebral small vessel disease patterns are associated with ischemic stroke in systemic lupus erythematosus. Lupus. Published 25 February 2025. doi:10.
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