Lupus & antiphospholipid syndrome
Epidemiological, immunological, and treatment response profile of patients with lupus nephritis in Brazil
Authors' conclusion
Late biopsy seems to be associated with negative renal outcomes in LN. However, it seems that a higher chronicity index is the main predictor of a poor renal outcome among patients with LN in Brazil.
Study context
- Population
- Patients diagnosed with lupus nephritis (LN) who underwent kidney biopsy 1999–2015, Nephrology Department, Hospital das Clínicas, São Paulo, Brazil
- Participants
- 398 patients
- Exposure
- Early biopsy vs late biopsy
- Outcome
- Clinical and epidemiological characteristics of LN and risk factors for poor renal prognosis
Methodological detailssingle-centre, Data collected from electronic medical records
- Single-centre
- Data collected from electronic medical records
Main finding
As reported in the abstract
Immunological profile
- ANA positive
- 94.1%
- Anti-DNA antibodies positive
- 77.7%
- Full-house pattern
- 33.7%
- Biopsy <6 months from symptom onset (early biopsy)
- 47.5%
- Biopsy ≥6 months from symptom onset (late biopsy)
- 52.5%
Observational data: associations, not effects.
Further findings
Chronicity and activity indices, early vs late biopsy
- In the early biopsy group, chronicity index lower and activity index higher
Risk factors for progression to kidney replacement therapy (multivariate analysis)
- Higher chronicity index was the only independent risk factor
Original publication
Epidemiological, immunological, and treatment response profile of patients with lupus nephritis in Brazil. Lupus. Published 21 March 2024. doi:10.
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