Lupus & antiphospholipid syndrome
Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary antiphospholipid syndrome (APS)
Authors' conclusion
Among PAPS patients classified by Sydney criteria, 16.6% did not meet 2023 ACR/EULAR criteria. One quarter of them had a thrombotic relapse, confirming a pro-thrombotic profile.
Study context
- Population
- Primary vascular APS (PAPS) patients meeting the Sydney criteria with previous vascular manifestations, followed 1992–2023
- Participants
- 205 participants
- Exposure
- PAPS patients meeting vs not meeting the 2023 ACR/EULAR APS classification criteria
- Met ACR/EULAR criterian = 171reference
- Did not meet ACR/EULAR criterian = 34
- Outcome
- Performance of the 2023 ACR/EULAR criteria (proportion of Sydney-classified PAPS not classified)
Methodological detailsre-classification of Sydney-classified PAPS by 2023 ACR/EULAR criteria
- Re-classification of Sydney-classified PAPS by 2023 ACR/EULAR criteria
Main finding
As reported in the abstract
Classification by 2023 ACR/EULAR criteria
Met ACR/EULAR criteria
171
events
Did not meet ACR/EULAR criteria
16.6%
34
- Not met due to isolate IgM positivity
- 23
- Not met due to aPL titer >99th percentile but <40 units
- 11
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Thrombotic relapse during follow-up in patients not confirmed as PAPS by 2023 ACR/EULAR criteria | Not confirmed as PAPS 26% |
- Thrombotic relapse during follow-up in patients not confirmed as PAPS by 2023 ACR/EULAR criteria: 9/34
Thrombotic recurrence, fulfilled vs not the new criteria
- Rate of thrombotic recurrence similar between patients who fulfilled or not the new criteria
Original publication
Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary APS. Rheumatology (Oxford). Published 17 December 2024. doi:10.
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