Lupus & antiphospholipid syndrome
Profile and clinical relevance of non-criteria antiphospholipid antibodies in patients diagnosed with or highly suspected of APS
Authors' conclusion
The prevalence of non-criteria aPLs differed from diagnostic biomarkers in patients diagnosed with or suspected of APS. Detection of aPLs provided additive value in the evaluation of APS-related clinical manifestations.
Study context
- Population
- Outpatients diagnosed with or highly suspected of APS, from a prospectively maintained database, and healthy controls16 non-criteria aPLs tested
- Participants
- 168 / 9 / 15 / 39 / 88
- Exposure
- Non-criteria aPLs across APS, seronegative APS (SNAPS), only-event, asymptomatic APA and healthy controls
- APSn = 168
- SNAPSn = 9
- Only-eventn = 15
- Asymptomatic APAn = 39
- Healthy controlsn = 88reference
- Outcome
- Positivity of non-criteria aPLs and relevance to clinical phenotypes
Methodological detailsprospectively maintained database, outpatient cases
- Prospectively maintained database
- Outpatient cases
Main finding
As reported in the abstract
Criteria aPL positivity (LA, aCL, anti-β2 glycoprotein-I)
LA
aCL
anti-β2 glycoprotein-I
- Patients negative for criteria serological tests positive for ≥1 non-criteria aPL
- 23 out of 24
Observational data: associations, not effects.
Original publication
Profile and clinical relevance of non-criteria antiphospholipid antibodies in patients diagnosed with or highly suspected of APS. Rheumatology (Oxford). Published 29 June 2023. doi:10.
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