Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)

Foddai, SG; Cecchi, I; Radin, M; Bertolaccini, L; de Andrade, D; Tektonidou, M; Pengo, V; Lopez-Pedrera, C; Paredes-Ruiz, D; Belmont, HM; Fortin, PR; Wahl, D; Branch, W; Gerosa, M; de Jesus, G; Zhang, Z; Atsumi, T; Efthymiou, M; Andreoli, L; Rodriguez, E; Petri, M; Cervera, R; Artim-Esen, B; Quintana, R; Knight, JS; Willis, R; Cobanoglu, RK; Cohen, H; Erkan, D; Sciascia, S

doi:10.1177/09612033261479899

Lupus & antiphospholipid syndrome

Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)

LupusPublished 3 Sep 2026Retrospective cohort study

Read the original article ↗PubMed

Cite

Authors' conclusion

In this international cohort of persistently aPL-positive individuals, 36% had single aPL positivity, mostly positive LA test.

Study context

Population: APS patients and aPL-positive patients without APS classification from the APS ACTION registry233 primary antiphospholipid syndrome (PAPS) and 97 aPL-positive tested
Participants: 84 vs 22

Exposure: Single aPL-positive PAPS vs single aPL-positive patients without APS classification
PAPSn = 84
No APS classificationn = 22reference
Outcome: Prevalence, clinical characteristics and CVD risk profile of persistently single aPL-positive PAPS

Methodological detailsregistry-based (APS ACTION), international

Registry-based (APS ACTION)
International

Main finding

As reported in the abstract

Single aPL positivity (prevalence)

Group	Value	LA positive	aCL IgG or IgM positive	aβ2GPI IgG or IgM positive
PAPS	36%	67 (79%)	8 (10%)	9 (11%)
No APS classification	22.7%	9	8	5

Value

PAPS36%

No APS classification22.7%

LA positive

PAPS67 (79%)

No APS classification9

aCL IgG or IgM positive

PAPS8 (10%)

No APS classification8

aβ2GPI IgG or IgM positive

PAPS9 (11%)

No APS classification5

Observational data: associations, not effects.

Further findings

Historical thrombosis recurrence in single aPL-positive PAPS: 26%
Historical thrombosis recurrence in single aPL-positive PAPS — Predominantly among those with LA positivity: 86%

Reference

Authors: Foddai SG, Cecchi I, Radin M, Bertolaccini L, de Andrade D, Tektonidou M, et al.
All 30 authors
Foddai SG, Cecchi I, Radin M, Bertolaccini L, de Andrade D, Tektonidou M, Pengo V, Lopez-Pedrera C, Paredes-Ruiz D, Belmont HM, Fortin PR, Wahl D, Branch W, Gerosa M, de Jesus G, Zhang Z, Atsumi T, Efthymiou M, Andreoli L, Rodriguez E, Petri M, Cervera R, Artim-Esen B, Quintana R, Knight JS, Willis R, Cobanoglu RK, Cohen H, Erkan D, Sciascia S
Journal: Lupus
Published: 3 Sep 2026
DOI: 10.1177/09612033261479899
PubMed: 42690699

Topic: Lupus & antiphospholipid syndrome

Exposure definitions

PAPS: PAPS patients with confirmed persistent single aPL positivity (LA, aCL IgG/IgM or aβ2GPI IgG/IgM), Revised Sapporo criteria
No APS classification: triple aPL-tested single aPL-positive patients with no APS classification (control)

Key notes

Single LA positivity significantly more common in PAPS; aCL IgM or aβ2GPI IgM positivity significantly more common in those without APS classification

Original publication

Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”). Lupus. Published 3 September 2026. doi:10.1177/09612033261479899

Read the original article ↗

Composed by AI from the published abstract and checked against it. How Briefs are made →